No. Verify the current official terms, obtain a category assessment under EB-1 or EB-2 and confirm admissibility first. A sale timed to a program whose conditions have not been checked risks a permanent loss of the business for an uncertain outcome.
Verify, assess, then sell
Hypothetical example: a Frontenac Islands couple are approached by a buyer for their resort and feel they must act quickly to fund the Gold Card. The sequence should run the other way. First, read the official program page and FAQ on the day of decision and save a dated copy, because the terms are recent and may be revised.
Second, obtain a written assessment of whether either spouse plausibly qualifies under EB-1 or EB-2, which is where the case will be decided. Third, review admissibility for both. Fourth, compare the route with a petition by their U.S.-citizen child if one is available.
Only then does a sale make sense, and it should be structured so that the closing does not depend on a program step that has not been reached. The processing fee is nonrefundable, so paying it before the assessment converts an open question into a sunk cost. Nothing about the program's timing requires a resort to be sold first.